Seth's interests center on networks and complex systems—how structures give rise to emergent behaviors like self-organization, adaptation, and resilience. He is particularly focused on building systems that design systems, exploring how these structures scale, interact, and shape their environment over time.

Applying this perspective, Seth has led teams in developing products to understand the structure and function of the internet, including its organizational and geopolitical dynamics. His work has shaped how organizations understand and navigate complex digital infrastructures, particularly in cybersecurity. Prior to this work, he led research to elucidate the regulatory networks that encode and control processes central to cell growth and cancer.